|Analysis methods||Availability||Number of genes||Test code||Retail Price|
|PCR||3 – 4 weeks||GHC 028||£ TBA|
A Gluten-free diet can now be considered a fashion trend. A lot of people now follow this
trend, including professional athletes. But for some they have not chosen this fashion
trend voluntarily. They had to adopt a gluten-free diet because of an autoimmune
disease called celiac disease.
Our genetic test can almost exclude the possibility of celiac disease occurring in your body, and in combination with immunoassay can also reduce the number of unpleasant endoscopies that are used to confirm the diagnosis of the disease.
Celiac disease is manifested by intolerance to gluten. This is found in most commonly used cereals (wheat, rye, barley, or a variety of varieties of oats) and in all the food produced from these cereals. Individuals with predispositions to celiac disease often have digestive problems that are not very specific. Diarrhea, or constipation, abdominal pain, flatulence, headaches and joints, chronic fatigue or concentration disturbances may occur. A severe form of celiac disease may also damage the small intestine mucosa.
The examination is appropriate if:
You have Down syndrome
You suspect refractory celiac disease
Children under 2 have celiac symptoms
Celiac disease has occurred with your immediate family
You have a gluten-free diet but have not been tested
Who is the test suitable for?
The mutation of this gene is 20% hereditary, therefore it is recommended especially for people with this disease in their family. HLA-DQ typing is recommended for patients with an unclear diagnosis, for those at increased risk of celiac disease - ie, the immediate relatives of a confirmed dg patient. celiac disease, patients with diseases having an association with celiac disease (e.g., DM 1 type).
What can this test reveal?
Genetic analysis of the DNA sample reveals whether there are variants of so-called HLA
genes associated with predispositions to the disease and whether further monitoring
or treatment is necessary. The only known causal treatment is lifelong adherence to a
gluten-free diet, so early diagnosis is important for early dieting.
35% of people have risky alleles in the genes that the test helps to detect. It also helps exclude celiac disease in unclear cases and determine the predisposition to the illness.
How does the test work?
Genetic examination is performed from your DNA, which can be obtained by swabbing from the oral cavity (buccal wiping of the inside of your mouth cheek - DNA isolation from oral mucosal cells). You can take the sample yourself in the comfort of your home and send it to our lab, or have your collection taken by your GP.
How is the test done?
You can order the test from attending your Doctor/GP, private clinic or online at ghcgenetics. co.uk. Once you have signed the informed consent form, either a swab of your mouth will be taken or a blood sample will be collected. Once the genetic analysis is finished, you or your Doctor/GP will receive a report with the results and based on these he/she will recommend suitable preventive measures.